中医外治MHD患者皮肤瘙痒临床研究(1)
摘要 目的：探讨以“养血活血、利湿化浊”立法中医辨证外用治疗MHD患者皮肤瘙痒的临床疗效。方法：选取2015年1月至2016年6月就诊的MHD皮肤瘙痒患者64例，随机分为治疗组和对照组各32例，对照组给予低磷饮食、基础治疗、血液透析每周3次，治疗组在对照组基础上以养血活血、利湿化浊中药辨证外治，观察2组治疗前后临床总有效率、皮肤瘙痒评分、血生化等指标变化。结果：临床总有效率比较：治疗组为93.7%，对照组为68.7%，两者统计学有统计学意义(P<0.01)；2组皮肤瘙痒评分与血生化比较：治疗组治疗后皮肤瘙痒评分、血BUN和IP水平与治疗前比较均有显著降低(P<0.05)，与对照组治疗后比较统计学也均有显著下降(P<0.05)；2组治疗后血Scr、CA、PTH比较明显变化(P<0.05)。结论：以“养血活血、利湿化浊”立法中医辨证外治，不仅可缓解MHD患者皮肤瘙痒，还有效降低了血BUN、IP水平，值得临床推广应用。
关键词 中医外治；MHD；皮肤瘙痒
Abstract Objective： To discuss the clinical effect on skin pruritus in Maintenance hemodialysis (MHD)patients with external treatment of Traditional Chinese Medicine (TCM )by means of “nourishing and activating blood， removing dampness and turbidity”.Methods： A total of 64 cases of MHD patients with skin pruritus treated during January 2015 to June 2016 were selected. They were randomly divided into treatment group and control group with 32 cases in each. The control group was given low-phosphorus diet with basic treatment and Hemodialysis three times a week. On the basis of the control group， external treatment was added to another group upon sysndrome differentiation with traditional Chinese herbs or prescriptions functioning as nourishing and activating blood， and removing dampness and turbid The total clinical effective rate， skin pruritus score and blood biochemical data were observed before and after the treatment. Results： The total clinical effective rate of treatment group was 93.7%， and control group was 68.7%. There was statistically significant difference between the two groups (P<0.01)； The comparison of skin pruritus score and blood biochemical data in the two groups： the skin pruritus score， levels of blood urea nitrogen and serum phosphorus of the treatment group were significantly decreased(P<0.05)； there was also significant reduction compared with the control group(P<0.05)； The two groups underwent obviously changes in the levels of serum creatinine、Serum calcium and serum parathyroid hormone (P<0.05). Conclusion： With the strategy of “nourishing and activating blood， removing dampness and turbid”based upon TCM syndrome differentiation， not only can skin pruritus be relieved from patients with MHD， but also levels of Blood urea nitrogen and Serum phosphorus are effectively reduced， which is worthy of clinical application.
Key Words Eexternal Treatment of Traditional Chinese Medicine； Maintenance Hemodialysis； Skin Pruritus
中圖分类号：R242文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.05.020, http://www.100md.com(边红萍 张胜荣 王小琴)
关键词 中医外治；MHD；皮肤瘙痒
Abstract Objective： To discuss the clinical effect on skin pruritus in Maintenance hemodialysis (MHD)patients with external treatment of Traditional Chinese Medicine (TCM )by means of “nourishing and activating blood， removing dampness and turbidity”.Methods： A total of 64 cases of MHD patients with skin pruritus treated during January 2015 to June 2016 were selected. They were randomly divided into treatment group and control group with 32 cases in each. The control group was given low-phosphorus diet with basic treatment and Hemodialysis three times a week. On the basis of the control group， external treatment was added to another group upon sysndrome differentiation with traditional Chinese herbs or prescriptions functioning as nourishing and activating blood， and removing dampness and turbid The total clinical effective rate， skin pruritus score and blood biochemical data were observed before and after the treatment. Results： The total clinical effective rate of treatment group was 93.7%， and control group was 68.7%. There was statistically significant difference between the two groups (P<0.01)； The comparison of skin pruritus score and blood biochemical data in the two groups： the skin pruritus score， levels of blood urea nitrogen and serum phosphorus of the treatment group were significantly decreased(P<0.05)； there was also significant reduction compared with the control group(P<0.05)； The two groups underwent obviously changes in the levels of serum creatinine、Serum calcium and serum parathyroid hormone (P<0.05). Conclusion： With the strategy of “nourishing and activating blood， removing dampness and turbid”based upon TCM syndrome differentiation， not only can skin pruritus be relieved from patients with MHD， but also levels of Blood urea nitrogen and Serum phosphorus are effectively reduced， which is worthy of clinical application.
Key Words Eexternal Treatment of Traditional Chinese Medicine； Maintenance Hemodialysis； Skin Pruritus
中圖分类号：R242文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.05.020, http://www.100md.com(边红萍 张胜荣 王小琴)
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